Mucin 6 (MUC6)(MUC6/916) , Biotin conjugate , 0.1mg / mL

The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid , proteases , pathogenic microorganisms , and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder , with lower expression in the terminal ileum and right colon. In gastric cancer , Mucin 6 has an altered expression. In normal stomach , Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia , duodenum and pancreas. Mucin 6 is a secretory mucin , located in the deeper mucosal folds of human gall bladder , and its expression is altered with increasing degrees of inflammation.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.