Aurora B (Proliferation Marker) (AURKB/1593) , CF594 conjugate , 0.1mg / mL

This antibody recognizes a protein of 39 kDa , which is identified as Aurora kinase B (or Aurora B). Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC) , a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation , cytokinesis , protein localization to the centromere and kinetochore , correct microtubule-kinetochore attachment , and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma , astrocytoma , seminoma and carcinomas of the colon , prostate , endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.